[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].
Identifieur interne : 002D79 ( Main/Exploration ); précédent : 002D78; suivant : 002D80[The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice].
Auteurs : Iu A. Desheva ; Kh Lu ; A R Rekstin ; D M Kats ; L G Rudenko ; A I KlimovSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Administration par voie nasale, Animaux, Anticorps antiviraux (sang), Basse température, Femelle, Hémagglutinines virales (génétique), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (sang), Protéines virales (génétique), Réactions croisées, Sialidase (génétique), Souris, Souris de lignée BALB C, Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N2 du virus de la grippe A (immunologie), Tests de neutralisation, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (génétique), Virus recombinants.
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- génétique : Hémagglutinines virales, Protéines virales, Sialidase, Vaccins antigrippaux, Vaccins atténués.
- immunologie : Sous-type H5N1 du virus de la grippe A, Sous-type H5N2 du virus de la grippe A, Vaccins antigrippaux.
- sang : Anticorps antiviraux, Infections à Orthomyxoviridae.
- Administration par voie nasale, Animaux, Basse température, Femelle, Infections à Orthomyxoviridae, Réactions croisées, Souris, Souris de lignée BALB C, Tests de neutralisation, Vaccination, Virus recombinants.
English descriptors
- KwdEn :
- Administration, Intranasal, Animals, Antibodies, Viral (blood), Cold Temperature, Cross Reactions, Female, Hemagglutinins, Viral (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N2 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Mice, Mice, Inbred BALB C, Neuraminidase (genetics), Neutralization Tests, Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (prevention & control), Reassortant Viruses, Vaccination, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (genetics), Viral Proteins (genetics).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Hemagglutinins, Viral, Influenza Vaccines, Neuraminidase, Vaccines, Attenuated, Viral Proteins.
- blood : Orthomyxoviridae Infections.
- immunology : Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N2 Subtype, Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Administration, Intranasal, Animals, Cold Temperature, Cross Reactions, Female, Mice, Mice, Inbred BALB C, Neutralization Tests, Reassortant Viruses, Vaccination.
Abstract
Classical genetic reassortant techniques were used to have a cold-adapted (ca) reassortant A/17/Duck/Potsdam/86/92 (H5N2) that inherited the hemagglutinin (HA) gene from the nonpathogenic avian virus A/Duck/Potsdam/ 1402-6186 (H5N2) and the genes of neuraminidase (NA) and non-glycated proteins from the ca attenuation donor A/Leningrad/134/17/57 (H2N2). All experiments were performed under increased biological protection (BSV-3+). The reassortant and parent H5N2 virus were non-pathogenic to Balb/c mice, the reassortant replication in the murine nasal passages (3.5 Ig EID50/ml) being higher than that in the lung (2.1 lg EID50/ml). Intranasal inoculation of mice with reassortant A/17/Duck/Potsdam/86/92 caused an immune response to both homological H5N2 virus and antigenically differing variants of influenza A (H5N1) virus isolated from humans in 1997 and 2003. The mice intranasally immunized with the ca reassortant were protected against fatal infection with the highly pathogenic A/Hong Kong/483/9797 (H5N1) virus and against infection with A/Hong Kong/213/03(H5N1) virus (80 and 100%, respectively).
PubMed: 17722607
Affiliations:
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Le document en format XML
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scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H5N2 Subtype</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Cold Temperature</term><term>Cross Reactions</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Reassortant Viruses</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Basse température</term><term>Femelle</term><term>Infections à Orthomyxoviridae</term><term>Réactions croisées</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term><term>Vaccination</term><term>Virus recombinants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Classical genetic reassortant techniques were used to have a cold-adapted (ca) reassortant A/17/Duck/Potsdam/86/92 (H5N2) that inherited the hemagglutinin (HA) gene from the nonpathogenic avian virus A/Duck/Potsdam/ 1402-6186 (H5N2) and the genes of neuraminidase (NA) and non-glycated proteins from the ca attenuation donor A/Leningrad/134/17/57 (H2N2). All experiments were performed under increased biological protection (BSV-3+). The reassortant and parent H5N2 virus were non-pathogenic to Balb/c mice, the reassortant replication in the murine nasal passages (3.5 Ig EID50/ml) being higher than that in the lung (2.1 lg EID50/ml). Intranasal inoculation of mice with reassortant A/17/Duck/Potsdam/86/92 caused an immune response to both homological H5N2 virus and antigenically differing variants of influenza A (H5N1) virus isolated from humans in 1997 and 2003. The mice intranasally immunized with the ca reassortant were protected against fatal infection with the highly pathogenic A/Hong Kong/483/9797 (H5N1) virus and against infection with A/Hong Kong/213/03(H5N1) virus (80 and 100%, respectively).</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Desheva, Iu A" sort="Desheva, Iu A" uniqKey="Desheva I" first="Iu A" last="Desheva">Iu A. Desheva</name><name sortKey="Kats, D M" sort="Kats, D M" uniqKey="Kats D" first="D M" last="Kats">D M Kats</name><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name><name sortKey="Lu, Kh" sort="Lu, Kh" uniqKey="Lu K" first="Kh" last="Lu">Kh Lu</name><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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